http://www.nlm.nih.gov/medlineplus/news/fullstory_98421.html

Scientists Unravel Secret of HIV Resistance
Gene that strengthens immune system may someday lead to vaccine, researchers say   
科学家揭开人体抗HIV能力的秘密
研究人员说，通过增强免疫系统的基因或可有朝一日能开发出疫苗

HealthDay    By Robert Preidt     Wednesday, May 5, 2010

WEDNESDAY, May 5 (HealthDay News) –
People who are resistant to HIV, the virus that causes AIDS, have a gene that gives them a stronger immune system, a new study shows.

A small number of people exposed to HIV -- about one in every 200 infected -- develop AIDS very slowly or never develop the disease. Previous research found that a large number of these naturally HIV-immune people have a gene called HLA B57.

一项新的研究显示，那些具有抗人类免疫缺陷病毒（HIV）免疫力的人体内有一种使免疫系统更强大的基因。艾滋病（AIDS）由HIV引起。

一小部分HIV感染者（大约每200个人中有1个人感染）会非常缓慢地发展为艾滋病或不患病。以往的研究发现，许多这些天生HIV-免疫人群携带HLA B57基因。

In this new study, U.S. researchers found that HLA B57 causes the body to produce more powerful killer T cells, which are white blood cells that attack infectious invaders. People with HLA B57 have a larger number of T cells that bind strongly to more pieces of HIV protein than people who don't have the gene. In people with HLA B57, T cells are more likely to recognize cells that express HIV proteins, including mutated versions that arise during infection.

在这项新的研究中，美国研究人员发现，HLA B57使机体产生更多杀伤T细胞（白细胞）攻击感染源。与无HLA B57基因的人们相比，有HLA B57基因的人们体内有更多的T细胞，牢固结合更多的HIV蛋白质片段。对于含有HLA B57的人，T细胞更可能识别出表达HIV蛋白质的细胞，包括感染过程中发生的变异类型。

The findings may help scientists develop vaccines that trigger the same immune response to HIV that occurs naturally in people with HLA B57, according to the researchers from the Ragon Institute of Massachusetts General Hospital, MIT and Harvard.

The study was published online May 5 in the journal Nature.

该研究发现可能有助于科学家开发出对HIV产生免疫应答的疫苗，该种免疫应答与携带HLA B57基因的人自然产生的应答相同，根据马萨诸塞州总医院拉贡研究所、麻省理工学院和哈佛大学的研究人员。

该项研究5月5日在线发表在《Nature》上。

SOURCE: MIT, news release, May 5, 2010